Marlo Jeffries, Ph.D.

My research program centers on elucidating the effects of contaminants of emerging concern on various physiological processes, especially those related to reproduction, development, and immunity. My lab is currently pursing three major lines of research: 1) Effects-directed analysis  to screen for and prioritize chemicals of emerging concern in urban and agricultural watersheds, 2) Elucidation of the impacts of exposures to endocrine disrupting compounds on thyroid hormone signaling, reproductive endocrine function, behavior, and immunity in fish and amphibians, and 3) Development of alternative methods for routine toxicity assessments and endocrine disruption screening. Graduate and undergraduate students working in my laboratory employ a wide variety of techniques, ranging from molecular and biochemical approaches (e.g., targeted gene expression analysis, transcriptomics, ELISAs, etc.) to whole-organism assays (e.g., pathogen resistance trials, behavioral assessments, etc.) to address specific questions within each of these research areas. Students interested in pursuing research with my team can learn more at http://www.tcujeffrieslab.com/. 

Allen DS, Kolok AS, Snow DD, Staybaldiyev B, Uralbekov B, Nystrom GS, Thornton Hampton LM, Bartelt-Hunt S, Sellin Jeffries MK. 2023. Predicted aquatic and human health risks associated with the presence of metals in the Syr Darya and Shardara Reservoir, Kazakhstan. Science of the Total Environment 859: 159827.

Thornton Hampton LM, Finch MG, Martyniuk CJ, Venables BJ, Sellin Jeffries MK. 2021. Early life stage thyroid hormone disruption causes long-term impacts on immune cell function and transcriptional responses to pathogen in the fathead minnow (Pimephales promelas). Scientific Reports 11:14496.

Krzykwa JC, King SM, Sellin Jeffries MK. 2021. Investigating the predictive power of three potential sublethal endpoints for the fish embryo toxicity test: snout-vent length, eye size and pericardial edema. Environmental Science and Technology 55, 6907-6916.

Thornton Hamptom LM, Martyniuk CJ, Venables BJ, Sellin Jeffries MK. 2020. Advancing the fathead minnow (Pimephales promelas) as a model for immunotoxicity testing: Characterization of the renal transcriptome following Yersinia ruckeri infection. Fish and Shellfish Immunology 103:472-480.

Roush KS, Sellin Jeffries MK. 2019. Sexual maturity status as a confounding variable in fish-based screening assays for the detection of anti-estrogens and non-aromatizable androgens. Environmental Toxicology and Chemistry 38:603-615.

Yost AY, Thornton LM, Venables BJ, Sellin Jeffries MK. 2016. Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles. Environmental Toxicology and Pharmacology 48:237-244.

Burchfiel E, Allen D, Wise C, Aldrete Z, Solomons K, Jeffries MK. 2023. Fluorescing fish: Using transgenic medaka to screen for environmental estrogens. South Central Chapter of the Society of Environmental Toxicology and Chemistry Annual Meeting, Denton, TX.

Solomons K, Allen D, Jeffries MK. 2023. Innovations in marine toxicity testing: Fish embryo and mysid tests as replacements for larval tests. South Central Chapter of the Society of Environmental Toxicology and Chemistry Annual Meeting, Denton, TX.

 Jeffries MK, Doyle K, Horton K. 2022. Development of a new infection model for fathead minnows, an emerging immunotoxicity model organism. Society of Environmental Toxicology and Chemistry 43^rd North America Annual Meeting, Pittsburgh, PA.

Allen DS, Wiencek M, Kelly M, Jeffries MK. 2022. Can tests with fish embryos or shrimp replace larval fish tests? – An initial evaluation of marine alternatives. Society of Environmental Toxicology and Chemistry 43^rd North America Annual Meeting, Pittsburgh, PA.

• Editor, Environmental Toxicology and Chemistry
• Associate Editor, Archives of Environmental Contamination and Toxicology
• Review Editor, Frontiers in Immunology
• Co-chair, Society of Environmental Toxicology and Chemistry Immunotoxicity Global Interest Group
• Co-chair, 2024 Socieity of Environmental Toxicology and Chemistry North America Annual Meeting
• Member, Health and Environmental Sciences Institute Next Generation Ecological Risk Assessment Committee

 

Honors

Exceptional reviewer (top 15 of nearly 850 reviewers) for Environmental Toxicology and Chemistry in 2018, 2020 and 2021

TCU Wassenich Award for Mentoring Nominee, 2018.

Nomination for Environmental Toxicology and Chemistry Best Paper of 2015; recognition appears in Environmental Toxicology and Chemistry, 35: 1605–1606.

Grants

Graduate Women in Science National Fellowship Program. 2022-2023. Identifying chemical hazards in aquatic systems: Validation of a small fish model to identify immunotoxic chemicals. $10,000. Awarded to Graduate Student, Rashidat Jimoh.

American Association of Laboratory Animal Sciences – Grants for Laboratory Animal Science (GLAS) program. 2021-2022. Moving Marine Fish Toxicity Tests Towards the 3Rs. $10,164. Marlo Jeffries (PI) and Dalton Allen (PhD student co-PI).

Society of Environmental Toxicology and Chemistry/ Procter & Gamble Fellowship for Research in Environmental Science. 2018-2019. Advancing animal alternatives in toxicity testing: The use of developmental abnormalities in fish embryos to predict chronic toxicity and adverse outcomes. $15,000. Awarded to Graduate Student, Julie Krzykwa.

American Association of Laboratory Animal Sciences – Grants for Laboratory Animal Science (GLAS) program. 2015-2016. Towards the 3R’s in fish toxicity testing. $27,192. Marlo Jeffries.

National Science Foundation – Catalyzing New International Collaborations (CNIC) Program. 2014-2015. Catalyzing New International Collaborations:  US-Kazakhstan workshop and pilot study- Pesticide occurrence and ecological effects in the Syr Darya River Basin. $49,751.  Dan Snow, Alan Kolok, Shannon Bartelt-Hunt and Marlo Jeffries.